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KMID : 0880220160540090583
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Journal of Microbiology
2016 Volume.54 No. 9 p.583 ~ p.587
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Multilayered regulations of RIG-I in the anti-viral signaling pathway
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Kim Na-Ri
Now He-Sung
Nguyen Nhung T. H.
Yoo Joo-Yeon
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Abstract
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RIG-I is a cytosolic receptor recognizing virus-specific RNA structures and initiates an antiviral signaling that induces the production of interferons and proinflammatory cytokines. Because inappropriate RIG-I signaling affects either viral clearance or immune toxicity, multiple regulations of RIG-I have been investigated since its discovery as the viral RNA detector. In this review, we describe the recent progress in research on the regulation of RIG-I activity or abundance. Specifically, we focus on the mechanism that modulates RIG-I-dependent antiviral response through post-translational modifications of or protein-protein interactions with RIG-I.
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KEYWORD
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RIG-I, antiviral signaling, RNA virus, post-translational modification, protein-protein interaction
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